Merseyside Police have confirmed they have begun a murder investigation after they were called to an incident earlier this afternoon.
A woman has been taken to hospital after an attack at a shop on Chapel Street.
A 30-year-old man was been detained at the scene.
Police confirmed he has now been arrested on suspicion of murder and is currently being held in custody.
A number of police vans and ambulances are on Chapel Street in the town centre and a police cordon is on place around TUI travel agents.
Police at the scene in central Southport
Other nearby shops have also been cordoned off, including Game, Vision Express and Carphone Warehouse – as well as TUI.
A statement from Merseyside Police said: “Merseyside Police can confirm a murder investigation has been launched following an incident in Southport today, Saturday 13th January.
“Officers were contacted at 1.25pm following reports that a 28 year-old woman had been injured at the Tui travel agents on Chapel Street. The woman was taken to hospital where she subsequently died from her injuries.
“The woman’s next of kin have been informed.
“It is believed that the incident was domestic-related.”
A large crowd has gathered around the cordoned off area in Southport
“The incident remains ongoing.”
Photos taken at the scene show the police cordon covering a large section of Chapel Street around the TUI travel agents.
A North West Ambulance Service spokeswoman confirmed they were called to Chapel Street at 1.27pm.
She said: “We got quite a lot of different resources there, we’ve got air ambulances and ambulances and a couple of our advanced paramedics.”
Two air ambulances were called to the scene in central Southport
Police cordoned off the area in Chapel Street, Southport
The victim was taken to Southport Hospital by road rather than air ambulance.
Express.co.uk has attempted to contact Merseyside Police on several occasions.
Anyone with information to contact Merseyside Police on 101 quoting log 470 of 13th January or the Crimestoppers line anonymously on 0800 555 111.