The Gunners have already recorded consecutive victories over Cologne and BATE, despite fielding largely fringe lineups, and a third win would see them go five points clear in Group H.
Follow all the action from Rajko Mitic Stadium as it happens, with kick-off at 6pm BST.
Red Star fans gather on a wall with anti-UEFA graffitti before the Europa League game
A merchandise seller displays match day scarves on a car outside the ground before the game
Only Petr Cech and Mohamed Elneny start from the team beaten 2-1 at Watrod in the Premier League last time out.
If you want a real comparison then there are three changes from the side that won 4-2 at BATE Borisov in Arsenal’s last European clash.
David Ospina makes way for Cech, while there are starts for Mathieu Debuchy and Francis COquelin as the injured Shkodran Mustafi and Per Mertesacker drop out the side.
Cech, Debuchy, Elneny, Holding, Nelson, Coquelin, Willock, Maitland-Niles, Walcott, Wilshere, Giroud.
Segregation is very much in force for this Europa League tie. I’d imagine only the die-hard Arsenal supporters have made their way out to Belgrade for this tie. One thing they won’t be left complaining about is the lack of atmosphere – it’s going to be a lively one among the home fans.
DREW RICHARDSON: Arsenal continue their Europa League campaign with a visit to Red Star Belgrade on Thursday night.
They are one of Eastern Europe’s better-known teams but have been out of the eye of the majority of football fans across Europe for much of the past two decades.
Here, Sportsmail takes a look at the team and provide a guide for fans who want to know a bit more about Arsenal’s opponents…
Red Star Belgrade have previous in winning the European Cup back in 1991
Riot police gather outside the Rajko Mitic Stadium before Red Star Belgrade's clash with Arsenal
Because Astana have just scored from the penalty spot following a handball.
That one game that has kicked off at 4pm? It’s currently goalless after half-an-hour. Our focus though is going to be on Arsenal this evening.
And that’s not just because all five English sides are top of their Champions League group at the halfway stage.
An Arsenal side made up of fringe players have been making easy work of the Europa League and they are in action again this evening as I welcome you to Sportsmail’s live coverage of the Gunners clash at Red Star Belgrade.