The Rockets moved to within just one win away from reaching the NBA Finals with an impressive 98-94 win over the Warriors last night.
In a frantic final minute of play, the Rockets showcased their tremendous defence to deny Golden State an opportunity to steal the win.
But there was also major concern when Paul fell to the floor clutching his hamstring.
The 33-year-old hinted after leaving the arena that he could be fine to feature in Game 6 tomorrow night.
Chris Paul went down clutching his hamstring in the final minute of the game
However, the team have announced that Paul will not play any part in the game.
The Houston Rockets tweeted: “@CP3 will miss Saturday’s game at Golden State with a right hamstring strain.
“He will be re-evaluated after the team returns to Houston.”
Rockets head coach Mike D’Antonio has revealed Eric Gordon will take Paul’s place in the starting line-up.
The Houston Rockets will have to battle against the Warriors without Chris Paul in Game 6
“It will not change anything we do and how we do it,” he said.
Paul played a crucial part in the Rockets winning Game 5, scoring 18 of his 20 points in the second half.
The Warriors have also had their injury issues this series with Andre Igoudala missing the last two games.
That has meant the likes of Kevin Durant and Draymond Green have had to play extended minutes in Igoudala’s absence.